In 2018 Lois was selected to serve on the powerful Appropriations Committee where she ensures Israel's funding for Iron Dome. She has signed onto letters that back security assistance to Israel with no additional political conditions and urged the administration to push back against politically motivated investigations of Israel by the International Criminal Court. Additionally, she rejected the Iran Nuclear Deal, voting against the agreement in 2015.

"Israel is the United States’ closest and most important ally in an increasingly unstable region. The bond between our two countries is rooted in our shared national interest as well as our shared values of democracy, rule of law, and the protection of basic human rights. This relationship strengthens both our nations. Israeli advancements in technology, medicine, and defense, help improve and protect the lives of people around the world." - Congresswoman Frankel